{"id":317,"date":"2021-08-19T08:56:07","date_gmt":"2021-08-19T08:56:07","guid":{"rendered":"https:\/\/medinaz.com\/blog\/?p=317"},"modified":"2022-01-04T06:46:50","modified_gmt":"2022-01-04T06:46:50","slug":"gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes","status":"publish","type":"post","link":"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/","title":{"rendered":"Gabapentin side effects, mechanism of action, uses &#8211; High yield Notes"},"content":{"rendered":"\n<p>High yield illustrated pharmacology notes of gabapentin side effects, mechanism of action, clinical uses, drug interaction, pharmacokinetics<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_55 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<p class=\"ez-toc-title\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-69d5368d5ba7e\"><span class=\"\"><span style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-69d5368d5ba7e\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Overview\" title=\"Overview\">Overview<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Gabapentin_Mechanism_of_action\" title=\"Gabapentin Mechanism of action\">Gabapentin Mechanism of action<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Pharmacokinetics\" title=\"Pharmacokinetics\">Pharmacokinetics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Clinical_uses_of_Gabapentin\" title=\"Clinical uses of Gabapentin\">Clinical uses of Gabapentin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Gabapentin_side_effects\" title=\"Gabapentin side effects\">Gabapentin side effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#What_type_of_drug_is_gabapentin\" title=\"What type of drug is gabapentin?\n\">What type of drug is gabapentin?\n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Does_gabapentin_make_you_gain_weight\" title=\"Does gabapentin make you gain weight?\n\">Does gabapentin make you gain weight?\n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#What_drugs_cannot_be_taken_with_gabapentin\" title=\"What drugs cannot be taken with gabapentin?\n\">What drugs cannot be taken with gabapentin?\n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Is_gabapentin_a_steroid\" title=\"Is gabapentin a steroid?\n\">Is gabapentin a steroid?\n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Is_gabapentin_an_anti_inflammatory_for_dogs\" title=\"Is gabapentin an anti inflammatory for dogs?\n\">Is gabapentin an anti inflammatory for dogs?\n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Is_gabapentin_an_anti_inflammatory_for_cats\" title=\"Is gabapentin an anti inflammatory for cats?\n\">Is gabapentin an anti inflammatory for cats?\n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/#Reference\" title=\"Reference:\">Reference:<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Overview\"><\/span>Overview<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Gabapentin is an <strong>amino acid<\/strong>, an <strong>analog of GABA<\/strong>, that is effective against partial seizures.<\/p>\n\n\n\n<p>Gabapentin was originally planned as a <strong>spasmolytic<\/strong> but it was found to be more effective as an <strong>antiseizure drug<\/strong>.<\/p>\n\n\n\n<p><strong>Pregabalin<\/strong> is another GABA analog and closely related to gabapentin. This drug has been approved for both antiseizure activity and for its analgesic properties.<\/p>\n\n\n\n<h2><span class=\"ez-toc-section\" id=\"Gabapentin_Mechanism_of_action\"><\/span><strong>Gabapentin Mechanism of action<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Gabapentin <strong>does not<\/strong> act directly on GABA receptors in spite of their close structural resemblance to GABA.<\/p>\n\n\n\n<p>They may, however, modify the synaptic or nonsynaptic release of GABA. An increase in brain GABA concentration is observed in patients receiving gabapentin.<\/p>\n\n\n\n<p>Gabapentin is transported into the brain by the <strong>L-amino acid transporter<\/strong>.<\/p>\n\n\n\n<p>Gabapentin binds avidly to the <strong>alpha-2-delta<\/strong> subunit of <strong>voltage-gated Ca2+ channels<\/strong>.<\/p>\n\n\n\n<p>This appears to underlie the main mechanism of action, which is <strong>decreasing Ca2+ entry<\/strong>, with a predominant effect on presynaptic N-type channels.<\/p>\n\n\n\n<p>A decrease in the synaptic release of glutamate provides the antiepileptic effect.<\/p>\n\n\n\n<p>In addition, gabapentin may exert an <strong>analgesic effect<\/strong> by <strong>activating descending inhibitory noradrenergic pathways<\/strong> that regulate neurotransmission of pain signals in the dorsal horn of the spinal cord. (<a href=\"https:\/\/pubs.asahq.org\/anesthesiology\/article\/119\/5\/1215\/13675\/Perioperative-GabapentinoidsChoice-of-Agent-Dose\" target=\"_blank\" rel=\"noreferrer noopener\">Ref<\/a>)<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"1024\" height=\"576\" src=\"https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-mechanism-of-action-1024x576.jpg\" alt=\"Gabapentin mechanism of action\" class=\"wp-image-318\" srcset=\"https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-mechanism-of-action-1024x576.jpg 1024w, https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-mechanism-of-action-300x169.jpg 300w, https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-mechanism-of-action-768x432.jpg 768w, https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-mechanism-of-action-1536x864.jpg 1536w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption>Gabapentin mechanism of action<\/figcaption><\/figure>\n\n\n\n<p class=\"has-background\" style=\"background-color:#ffe499;line-height:0\"><strong>Points to Remember<\/strong><\/p>\n\n\n\n<p class=\"has-background\" style=\"background-color:#d8f3ff\">Gabapentin has <strong>no<\/strong> activity at GABAA or GABAB receptors of GABA uptake carriers of brain<\/p>\n\n\n\n<h2><span class=\"ez-toc-section\" id=\"Pharmacokinetics\"><\/span><strong>Pharmacokinetics<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Gabapentin is <strong>not <\/strong>metabolized and <strong>does not<\/strong> induce hepatic enzymes.<\/p>\n\n\n\n<p>Absorption is nonlinear and dose-dependent at very high doses, but the elimination kinetics are linear.<\/p>\n\n\n\n<p><em>Gabapentin <\/em><strong>does not bind<\/strong> to <strong>plasma proteins<\/strong> and is <strong>excreted unchanged<\/strong> through the kidneys.<\/p>\n\n\n\n<p>Reduced dosing is required in renal disease<\/p>\n\n\n\n<p>Half-life is <strong>5-8 hours<\/strong><\/p>\n\n\n\n<h2><span class=\"ez-toc-section\" id=\"Clinical_uses_of_Gabapentin\"><\/span><strong>Clinical uses of Gabapentin<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Gabapentin is effective as an adjunct against <strong>partial seizures<\/strong> and <strong>generalized tonic-clonic seizures<\/strong><\/p>\n\n\n\n<p>Gabapentin is considered to be a <strong>first line drug<\/strong> for neuralgic pain due to <strong>diabetic neuropathy<\/strong> and <strong>postherpetic neuralgia<\/strong>.<\/p>\n\n\n\n<p>It has some <strong>prophylactic effect in migraine<\/strong> and is an alternative drug for <strong>phobic states<\/strong><\/p>\n\n\n\n<p>It is also helpful to reduce pain related to <strong>multiple sclerosis<\/strong><\/p>\n\n\n\n<p>Gabapentin is also approved for the treatment of <strong>Bipolar disorder<\/strong> and <strong>Generalized anxiety disorder<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"1024\" height=\"576\" src=\"https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-uses-1024x576.jpg\" alt=\"Gabapentin uses mnemonic\" class=\"wp-image-319\" srcset=\"https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-uses-1024x576.jpg 1024w, https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-uses-300x169.jpg 300w, https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-uses-768x432.jpg 768w, https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-uses-1536x864.jpg 1536w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption>Gabapentin uses <a href=\"https:\/\/medinaz.com\/shop\" target=\"_blank\" rel=\"noreferrer noopener\">mnemonic<\/a><\/figcaption><\/figure>\n\n\n\n<p class=\"has-background\" style=\"background-color:#ffe499;line-height:0\"><strong>Points to remember<\/strong><\/p>\n\n\n\n<ul class=\"has-background\" style=\"background-color:#d7f3ff\"><li>Gabapentin <strong>increases GABAergic transmission<\/strong> by increasing its synthesis and release.<\/li><li>Its absorption from GIT is <strong>saturable<\/strong>, therefore it is <strong>safe even after overdosing<\/strong><\/li><\/ul>\n\n\n\n<h2><span class=\"ez-toc-section\" id=\"Gabapentin_side_effects\"><\/span><strong>Gabapentin side effects<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Dizziness and drowsiness<\/p>\n\n\n\n<p>Somnolence<\/p>\n\n\n\n<p>Fatigue<\/p>\n\n\n\n<p>Weight gain<\/p>\n\n\n\n<p>Uncoordinated movement<\/p>\n\n\n\n<p>Dry mouth<\/p>\n\n\n\n<p>Behavioural changes<\/p>\n\n\n\n<p>Suicidal thoughts<\/p>\n\n\n\n<p>Breathing difficulties with opioids and other CNS depressants<\/p>\n\n\n\n<p><\/p>\n\n\n\t\t<section\t\tclass=\"sc_fs_faq sc_card    \"\n\t\t\t\t>\n\t\t\t\t<h2><span class=\"ez-toc-section\" id=\"What_type_of_drug_is_gabapentin\"><\/span>What type of drug is gabapentin?\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\t\t\t\t<div>\n\t\t\t\t\t\t<div class=\"sc_fs_faq__content\">\n\t\t\t\t\n\n<p>Gabapentin is an anticonvulsant group of drug. Gabapentin decreases abnormal excitement in brain and helps to treat seizures. Gabapentin is the drug of choice for post herpetic neuralgia related pain.<\/p>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section\t\tclass=\"sc_fs_faq sc_card    \"\n\t\t\t\t>\n\t\t\t\t<h2><span class=\"ez-toc-section\" id=\"Does_gabapentin_make_you_gain_weight\"><\/span>Does gabapentin make you gain weight?\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\t\t\t\t<div>\n\t\t\t\t\t\t<div class=\"sc_fs_faq__content\">\n\t\t\t\t\n\n<p>Weight gain and uncoordinated movement are possible side effects of gabapentin<\/p>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section\t\tclass=\"sc_fs_faq sc_card    \"\n\t\t\t\t>\n\t\t\t\t<h2><span class=\"ez-toc-section\" id=\"What_drugs_cannot_be_taken_with_gabapentin\"><\/span>What drugs cannot be taken with gabapentin?\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\t\t\t\t<div>\n\t\t\t\t\t\t<div class=\"sc_fs_faq__content\">\n\t\t\t\t\n\n<p>Gabapentin can interact with Losartan, ethacrynic acid, phenytoin, mefloquine, magnesium oxide, cimetidine, naproxen, morphine and caffeine. Gabapentin use is contraindicated in patients with myasthenia gravis or myoclonus.<\/p>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section\t\tclass=\"sc_fs_faq sc_card    \"\n\t\t\t\t>\n\t\t\t\t<h2><span class=\"ez-toc-section\" id=\"Is_gabapentin_a_steroid\"><\/span>Is gabapentin a steroid?\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\t\t\t\t<div>\n\t\t\t\t\t\t<div class=\"sc_fs_faq__content\">\n\t\t\t\t\n\n<p>Gabapentin is not a steroid. It is used as an anticonvulsant, sedative and anxiolytic to treat chronic pain syndromes, including neuropathic pain.<\/p>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section\t\tclass=\"sc_fs_faq sc_card    \"\n\t\t\t\t>\n\t\t\t\t<h2><span class=\"ez-toc-section\" id=\"Is_gabapentin_an_anti_inflammatory_for_dogs\"><\/span>Is gabapentin an anti inflammatory for dogs?\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\t\t\t\t<div>\n\t\t\t\t\t\t<div class=\"sc_fs_faq__content\">\n\t\t\t\t\n\n<p>Gabapentin is used in dogs to treat chronic pain, particularly of neuropathic origin. It appears to be most effective when combined with other types of analgesic agents like NSAIDs<\/p>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section\t\tclass=\"sc_fs_faq sc_card    \"\n\t\t\t\t>\n\t\t\t\t<h2><span class=\"ez-toc-section\" id=\"Is_gabapentin_an_anti_inflammatory_for_cats\"><\/span>Is gabapentin an anti inflammatory for cats?\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\t\t\t\t<div>\n\t\t\t\t\t\t<div class=\"sc_fs_faq__content\">\n\t\t\t\t\n\n<p>Gabapentin is used in cats to treat chronic pain, particularly of neuropathic origin. It appears to be most effective when combined with other types of analgesic agents like NSAIDs<\/p>\n\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t<\/section>\n\t\t\n<script type=\"application\/ld+json\">\n\t{\n\t\t\"@context\": \"https:\/\/schema.org\",\n\t\t\"@type\": \"FAQPage\",\n\t\t\"mainEntity\": [\n\t\t\t\t\t{\n\t\t\t\t\"@type\": \"Question\",\n\t\t\t\t\"name\": \"What type of drug is gabapentin?\n\",\n\t\t\t\t\"acceptedAnswer\": {\n\t\t\t\t\t\"@type\": \"Answer\",\n\t\t\t\t\t\"text\": \"<p>Gabapentin is an anticonvulsant group of drug. Gabapentin decreases abnormal excitement in brain and helps to treat seizures. Gabapentin is the drug of choice for post herpetic neuralgia related pain.<\/p>\"\n\t\t\t\t\t\t\t\t\t}\n\t\t\t}\n\t\t\t,\t\t\t\t{\n\t\t\t\t\"@type\": \"Question\",\n\t\t\t\t\"name\": \"Does gabapentin make you gain weight?\n\",\n\t\t\t\t\"acceptedAnswer\": {\n\t\t\t\t\t\"@type\": \"Answer\",\n\t\t\t\t\t\"text\": \"<p>Weight gain and uncoordinated movement are possible side effects of gabapentin<\/p>\"\n\t\t\t\t\t\t\t\t\t}\n\t\t\t}\n\t\t\t,\t\t\t\t{\n\t\t\t\t\"@type\": \"Question\",\n\t\t\t\t\"name\": \"What drugs cannot be taken with gabapentin?\n\",\n\t\t\t\t\"acceptedAnswer\": {\n\t\t\t\t\t\"@type\": \"Answer\",\n\t\t\t\t\t\"text\": \"<p>Gabapentin can interact with Losartan, ethacrynic acid, phenytoin, mefloquine, magnesium oxide, cimetidine, naproxen, morphine and caffeine. Gabapentin use is contraindicated in patients with myasthenia gravis or myoclonus.<\/p>\"\n\t\t\t\t\t\t\t\t\t}\n\t\t\t}\n\t\t\t,\t\t\t\t{\n\t\t\t\t\"@type\": \"Question\",\n\t\t\t\t\"name\": \"Is gabapentin a steroid?\n\",\n\t\t\t\t\"acceptedAnswer\": {\n\t\t\t\t\t\"@type\": \"Answer\",\n\t\t\t\t\t\"text\": \"<p>Gabapentin is not a steroid. It is used as an anticonvulsant, sedative and anxiolytic to treat chronic pain syndromes, including neuropathic pain.<\/p>\"\n\t\t\t\t\t\t\t\t\t}\n\t\t\t}\n\t\t\t,\t\t\t\t{\n\t\t\t\t\"@type\": \"Question\",\n\t\t\t\t\"name\": \"Is gabapentin an anti inflammatory for dogs?\n\",\n\t\t\t\t\"acceptedAnswer\": {\n\t\t\t\t\t\"@type\": \"Answer\",\n\t\t\t\t\t\"text\": \"<p>Gabapentin is used in dogs to treat chronic pain, particularly of neuropathic origin. It appears to be most effective when combined with other types of analgesic agents like NSAIDs<\/p>\"\n\t\t\t\t\t\t\t\t\t}\n\t\t\t}\n\t\t\t,\t\t\t\t{\n\t\t\t\t\"@type\": \"Question\",\n\t\t\t\t\"name\": \"Is gabapentin an anti inflammatory for cats?\n\",\n\t\t\t\t\"acceptedAnswer\": {\n\t\t\t\t\t\"@type\": \"Answer\",\n\t\t\t\t\t\"text\": \"<p>Gabapentin is used in cats to treat chronic pain, particularly of neuropathic origin. It appears to be most effective when combined with other types of analgesic agents like NSAIDs<\/p>\"\n\t\t\t\t\t\t\t\t\t}\n\t\t\t}\n\t\t\t\t\t\t]\n\t}\n<\/script>\n\n\n\n<h2><span class=\"ez-toc-section\" id=\"Reference\"><\/span>Reference:<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/amzn.to\/2VOzpMN\" target=\"_blank\" rel=\"noreferrer noopener\">Basic and Clinical Pharmacology; Bertram G. Katzung; 14th ed<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/amzn.to\/3s8anEK\" target=\"_blank\" rel=\"noreferrer noopener\">The Pharmacological Basis of Therapeutics; Goodman &amp; Gilman&#8217;s; 13th ed<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/amzn.to\/3fWcFlu\" target=\"_blank\" rel=\"noreferrer noopener\">Essentials of Medical Pharmacology; KD Tripathi; 7th ed<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/amzn.to\/3fXaDBw\" target=\"_blank\" rel=\"noreferrer noopener\">Visual Book Of Pharmacology, Microbiology, Pathology and Immunology (Medical Mnemonics); Nazmul Alam; 1st ed<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/amzn.to\/3fXaZYS\" target=\"_blank\" rel=\"noreferrer noopener\">Review of Pharmacology; Garg &amp; Gupta; 14th ed<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>High yield illustrated pharmacology notes of gabapentin side effects, mechanism of action, clinical uses, drug interaction, pharmacokinetics Overview Gabapentin is an amino acid, an analog of GABA, that is effective against partial seizures. Gabapentin was originally planned as a spasmolytic but it was found to be more effective as an antiseizure drug. Pregabalin is another<\/p>\n","protected":false},"author":1,"featured_media":330,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ub_ctt_via":""},"categories":[43,62],"tags":[68,46,64,69],"featured_image_src":"https:\/\/medinaz.com\/blog\/wp-content\/uploads\/2021\/08\/Gabapentin-High-yield-pharmacology-notes.jpg","author_info":{"display_name":"Medinaz Academy","author_link":"https:\/\/medinaz.com\/blog\/author\/medinaz-blog-admin\/"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gabapentin side effects, mechanism of action, uses - High yield Notes -<\/title>\n<meta name=\"description\" content=\"Gabapentin side effects, mechanism of action, clinical uses, drug interaction, pharmacokinetics - High yield illustrated pharmacology notes\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medinaz.com\/blog\/2021\/08\/19\/gabapentin-side-effects-mechanism-of-action-uses-high-yield-notes\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gabapentin side effects, mechanism of action, uses - 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