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Top 100 High-yield Biochemistry Topics for USMLE Step 1 Exam

Biochemistry is a foundational subject for the USMLE Step 1 exam and is crucial for several reasons:

  1. Understanding Disease Mechanisms: Biochemistry helps understand the molecular and biochemical underpinnings of diseases. Knowledge of pathways such as glycolysis, the citric acid cycle, and lipid metabolism is essential to understand how abnormalities in these pathways can lead to clinical conditions. For instance, understanding mitochondrial dysfunctions helps explain diseases like mitochondrial myopathies.
  2. Pharmacological Applications: Many drugs target specific enzymes and pathways discussed in biochemistry. For example, understanding the cholesterol synthesis pathway is vital for comprehending how statins work to lower cholesterol levels.
  3. Genetics and Molecular Biology: Biochemistry is closely tied to genetics and molecular biology, areas heavily tested on the USMLE Step 1. Understanding DNA replication, repair, and transcription processes are crucial for diagnosing and treating genetic disorders.
  4. Diagnostic Tools: Biochemical tests are part of routine medical diagnostics. Knowledge of biochemistry is necessary to interpret results of various blood tests, enzyme markers, and metabolic levels, which are integral to making clinical decisions.
  5. Metabolism and Nutrition: A solid grasp of metabolism is crucial for understanding nutritional needs and managing metabolic disturbances, such as diabetes mellitus or metabolic syndrome, which are common topics on the exam.
  6. Integration with Other Disciplines: Biochemistry integrates with other medical sciences like physiology, pathology, and pharmacology, making it essential for a holistic understanding of medicine. The USMLE Step 1 exam tests this integrated knowledge extensively.

Top 100 High-yield Biochemistry Topics for USMLE Step 1

Here is the list of Top 100 High-yield Biochemistry Topics for USMLE Step 1 exam in Alphabetic order:

  1. Alcohol Metabolism
  2. Amino Acid Absorption
  3. Amino Acid Catabolism
  4. Amino Acids
  5. Apolipoproteins
  6. Blotting
  7. Cell Cycle
  8. Cell Surface Proteins
  9. Chediak Higashi
  10. Cholesterol
  11. Chromatin Structure
  12. Chromosomal Diseases
  13. Chromosomal Structure
  14. Citric Acid Cycle
  15. Collagen
  16. Collagen and Elastin Basics
  17. Cytoskeleton Basics
  18. Cystinuria
  19. De Novo Nucleotide Synthesis
  20. Dietary Energy Content
  21. DNA Repair
  22. DNA Replication
  23. Ehlers Danlos
  24. Electron Transport Chain
  25. Elastin
  26. Endoplasmic Reticulum
  27. Epigenetics
  28. Ethanol Metabolism
  29. Extracellular Matrix
  30. Fabry disease
  31. Fat Soluble Vitamins
  32. Fatty Acid Metabolism
  33. Fructose Disorder
  34. Fructose Metabolism
  35. Galactose Disorder
  36. Galactose Metabolism
  37. Gaucher disease
  38. Gene Organization
  39. Genetic Principles
  40. Gluconeogenesis
  41. Glucose Transport
  42. Glycogen
  43. Glycolysis
  44. Golgi Apparatus
  45. Hartnup Disease
  46. Heme Metabolism
  47. HMP Shunt
  48. Hurler
  49. I Cell Disease
  50. Intermediate Filaments
  51. Kartagners Syndrome
  52. Karyotyping
  53. Ketone Bodies
  54. Kwashiorkor and Marasmus
  55. Lysosome
  56. Maple Syrup Urine Disease
  57. McCardles
  58. Metabolism of Exercise and Starvation
  59. Metabolism Overview
  60. Methanol Poisoning
  61. Microarrays
  62. Microtubules
  63. Mitochondria
  64. Modes of Inheritance
  65. Nucleotide Catabolism/Salvage
  66. Nucleus
  67. Osteogenesis Imperfecta
  68. OTC Deficiency
  69. Peroxisome
  70.  Proteasome
  71. PKU
  72. Plasma Membrane
  73. Polymerase Chain Reaction (PCR)
  74. Population Genetics
  75. Post-Translational Modification
  76. Propionic Acid Pathway
  77. Protein Folding and Degradation
  78. Protein Structure
  79. Protein Synthesis
  80. Pyruvate Dehydrogenase Complex
  81. Pyruvate Metabolism
  82. Reverse Transcription
  83. RNA Polymerases
  84. RNA Processing
  85. RNA Types
  86. Signal Transduction
  87. Sorbitol
  88. Specifics about cilia structure
  89. Smooth vs. rough endoplasmic reticulum
  90. Tay-Sachs disease
  91. Trace Metals
  92. Transcription
  93. Transcription Regulation
  94. Triglycerides
  95. Trinucleotide Repeat Expansion Diseases
  96. Type of DNA Mutations
  97. tRNA
  98. Universal Electron Acceptors
  99. Von Gierkes disease
  100. Water Soluble Vitamins

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